Endocrine Abstracts

Aim: Increased thyroid volume and thyroid dysfunction (TD) in diabetics have been reported. The aim of this study is to investigate the prevalence of thyroid disorders in patients with type 2 diabetes mellitus in formerly iodine deficient area.Methods: We included 131 (73 females and 58 males) diabetics without a history of previous thyroid disease and symptoms. The demographic, medical and clinical data, laboratory results (fasting plasma glucose (FPG),...

Background and aims: Obesity, as a central piece inside metabolic syndrome, is as an independent risk factor for the onset, aggravated course, and poor outcomes of chronic kidney disease (CKD) including diabetic nephropathy (DN). Our aim was to investigate the relationship between metabolic syndrome (MS), diabetic nephropathy and renal function in patients with type 2 diabetes mellitus (T2DM).Materials and Methods: 197 patients with T2DM (mean age; 56.1&...

Introduction: Permanent hypothyroidism is a common side effect of thyroidectomy. Thyroxine binding globulin (TBG) deficiency is characterized with low total thyroid hormones (TH) in the presence of normal free THs and thyroid stimulating hormone (TSH).Case report: A previously healthy 37-year-old man underwent annual health check-up. Thyroid US revealed a 24×14×19 mm isoechoic solid nodule in the left lobe. TSH was 1.4 (0.27–4.2 μIU/m...

Introduction: Glucocorticoids, even endogenous or exogenous, suppress the inflammatory response therefore they are the most preferred treatment options in inflammatory diseases. Persistent hypercortisolism induces lymphopenia and lymphoid tissue atrophy. Excessive endogenous hypercortisolism might mask the active inflammatory disease. Rebound immune modulation may occur after Cushing’s syndrome (CS) remission, leading to the new onset of autoimmune diseases.<p class="...

Introduction: Primary aldosteronism (PA) is the most common reason for secondary hypertension. Among adrenal disorders, rarely aldosterone- and cortisol-co-secreting adenomas (A/CPA) can lead to PA. 35 patients with A/CPA were reported to date and their mean age was 52 (range 34–80) years. We report an A/CPA in an adolescent girl presenting with hypertension combined with hypokalemia and signs of hypercortisolism.Case report: A 18-year-old girl admi...

Hashimoto thyroiditis (HT) is the most common cause of hypothyroidism. Subacute thyroiditis (SAT) is an uncommon disease with characteristic clinical features. Co-existence of HT and SAT is very rare and diagnosis can be challenging.Case: A 42-year-old woman with HT and multinodular goitre under levothyroxine sodium (LT4) therapy admitted to internal medicine clinic with 1 month history of anterior neck pain radiating to jaw. Thyroid function ...

Background: Millions of Muslims fast from dawn until dusk during the annual Islamic holy month of Ramadan. Most of the studies evaluating biochemical changes in diabetic patients during Ramadan showed little changes in the glycemic control. In this study, our aim was to assess the impact of fasting during Ramadan on glycemic control in patients with type 2 diabetes.Methods and design: We examined 122 patients with type 2 diabetes (82 females, 40 males, a...

Background: Cushing’s syndrome (CS) is a relatively unusual condition that resembles many of the phenotypic features of obesity. The 1-mg dexamethasone suppression test (1 mg-DST) is the most frequently used screening tool for CS. However, the lack of suppression after 1-mg DST may be found in obese patients. In the current study, our aim was to evaluate the clinical signs of CS and the 1 mg-DST in obese patients.Materials and methods: 354 patients ...

Aim: Nonenzymatic advanced glycation and oxidation end-products, advanced glycation end-products (AGEs), impart a potent impact on vessels in diabetic state and in euglycaemic conditions with increased oxidative stress.The aim of this study is to measure AGEs and its relationship with carotid intimae media thickness (CIMT) in acromegaly patients.Method: A case–control study was performed in 225 acromegalic patients (F/M: 116/1...

Introduction: Polyglandular autoimmune syndrome (PAS) is a syndrome that is characterized by the association of two or more organ specific autoimmune disorders. Collagenous mucosal inflammatory diseases involve the columnar-lined gastric and intestinal mucosa. The coexistence of the two disease has not been reported. We have encountered a patient with a rare combination of autoimmune thyroiditis, hypoparathyroidism, primary ovarian failure and collagenous sprue. To our knowled...